Sonodynamic Therapy

[keli]

Does anyone have information on Sonodynamic therapy for DIPG? our 4 yo child was diagnosed 6 months ago

[musella]

https://clinicaltrials.gov/ct2/show/NCT05123534

[keli]

so what I understand is that Sonodynamic is offered only within a trial, what about photodynamic therapy with ICG nanoparticles? I know of a clinic near me that is offering it do you know it's efficacy in high grade gliomas?

[musella]

Right now in the USA sonodynamic therapy is only available in clinical trials. Hopefully expanded access will start when the current trials report their data
I do not know the results of the photodynamic therapy treatment but it just doesn’t make sense to me that they could hit enough of the brain with light.

[netopolis]

This is why photodynamic therapy is not done on large tumors, it's usually done on inoperable smaller tumor residues. This is what I gathered from limited resource on photodynamic therapy. I've even found a clinic in Australia that does PDT but evidence of efficiency is limited. This is the only paper with decent level of evidence https://link.springer.com/article/10...60-023-04284-9 . I skimmed trough the paper so I'm not sure if Australian clinic uses the same methods.

I asked the mentioned clinic about the approximate price of PDT but I never got an answer.
If someone has experience with this kind of therapy, knows about other clinics that use PDT or succeeds in getting reply from the mentioned clinic I would appreciate hearing about it.

This is the Australian clinic I was referring to https://www.nextgenerationpdt.com/.

I agree with Al, hough light with long wave lengths can penetrate small portion of brain tissue sonodynamic therapy makes more sense and it's been tested for better drug delivery into the brain tissue. On the other hand, PDT seems to be available already and who knows how long we will have to wait for SDT outside of the clinical trials.

[JoeS]

I'm sorry to hear about your child's diagnosis. DIPG (Diffuse Intrinsic Pontine Glioma) is a rare and aggressive type of brain cancer that affects children.

Sonodynamic therapy (SDT) is a type of cancer treatment that uses ultrasound waves in combination with a special type of chemical called a sonosensitizer to kill cancer cells. The sonosensitizer is injected into the bloodstream, where it accumulates in cancer cells. When ultrasound waves are applied to the area where the cancer cells are located, the sonosensitizer reacts with the ultrasound waves, generating toxic molecules that kill the cancer cells.

While there have been some promising preclinical studies on the use of SDT for DIPG, specialists from https://www.riviamind.com/ affirm that there is currently no approved sonodynamic therapy for the treatment of DIPG. Clinical trials are ongoing to determine the safety and effectiveness of SDT for DIPG, but it is still considered an experimental treatment.