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Cancer having a biological clock and some additional research information

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  • Cancer having a biological clock and some additional research information

    I ran into this article which I found fascinating about cancer having a biological (circadian) clock in its ability to slow down the of cell division and thus, slowing growth. This idea, in theory, should slow down its growth and also allow for treatments to work better on cancer cells. This struck me as a very interesting approach to research some more.

    https://www.sciencedaily.com/release...0123144524.htm

    I looked into it more and they are using a proprietary molecule (GO289) in the study to slow down the cancer cells.As i was not going to find the makeup of this molecule, the article indicated the molecule targets the CK-2 enzyme.

    I did more investigation to find the CK-2 iinteracts with the Wnt and NF-Kb signalling pathways to promote tumorigenisis.
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905806/


    So I looked into drugs that may inhibit CK-2 and found the most potent inhibitor of CK-2 is Ellagic Acid:
    https://www.ncbi.nlm.nih.gov/pubmed/16610779

    Interestingly enough, Ellagic Acid is available as an over the counter supplement but, also, the best sources come from pomegranate juice and grapes.

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596197/

    So I tried to find if studies existed for cancer and pomegranite juice or ellagic acid and found this:
    https://www.mayoclinic.org/diseases-...e/faq-20058204

    The interesting information from this study as it was related to prostrate cancer which uses PSA tests an indicator of cancer growth. In this study, the pomegranite juice showed a slowing of the rate at which the prostate recurrent cancer grew or was eliminated. This would seem to support the original idea of cancer having a biological clock and there is an ability to slow down its growth.

  • #2
    Fascinating but I would like to see some research on people. Things get too complicated in the human body. For example If something slows down all cells, it might slow down the immune cells you need to fight the tumor as well... so even if you slow the tumor, in the long run it hurts more than it helps.

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    • #3
      This is the perfect project for our virtual trial.... we could compare people who used things like this on a daily basis and compare them to similiar people with the same tumor type and major biomarkers and see which group did better.
      We do not have enough patients in the project yet to do that, and we did not have pomegranite juice as a supplment we are following so I just added it now. If anyone is going to try it - make sure to join the virtual trial registery first!

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      • #4
        Originally posted by musella View Post
        Fascinating but I would like to see some research on people. Things get too complicated in the human body. For example If something slows down all cells, it might slow down the immune cells you need to fight the tumor as well... so even if you slow the tumor, in the long run it hurts more than it helps.
        All good points. The GO289 research did indicate it targeted only cancer cells and not healthy cells. CK-2 exists in cancer cells and healthy cells. However, up-regulation occurs in both cell types (healthy and unhealthy) when cancer is present after skimming through this research about the CK2 protein (I have not had time to digest it yet). Perhaps you would be returning healthy cells to a normal state and by dysregulating CK2, cancer cells need the upregulation to survive but healthy cells return to normal levels.
        https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385580/

        I found a better detailed article about the Phase 2 test of pomegranate juice and prostate cancer PSA test and its results.
        https://clincancerres.aacrjournals.o...ent/12/13/4018

        I found the correlation interesting (GO289 as a CK2 target, finding novel CK2 targets, and the testing of the novel CK2 targets). However, as you said, there are many factors in the body that could impact this research (blood brain barrier penetration, liver absorption, etc) in comparison to the PSA test. I went back and looked at other people's cocktails from other sites and did not see anyone using a CK2 inhibitor as part of their daily routine. Perhaps a new approach or maybe someone knows something I do not?

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        • #5
          It seems like such a simple thing to try. One 8 ounce glass of juice a day/ Have you ever tasted pomegranate juice? I never have. Is it good?

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          • #6
            Originally posted by musella View Post
            It seems like such a simple thing to try. One 8 ounce glass of juice a day/ Have you ever tasted pomegranate juice? I never have. Is it good?
            Yes, I started on it after the research. I drink it when I take my morning pills. It's like grape juice but a more tart. The Pom juice brand is expensive but I am able to find other brands much cheaper.

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            • #7
              Good luck with it. Make sure to record your experiences in the virtual trial

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              • #8
                I don't know what you mean by sharing in a virtual trial.

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                • #9
                  Go to virtualtrials.com click on Virtual Trial. Read about it and join. It is a registry where we track the treatments you do and the outcome!

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